Ca+2 ATPase of plasma membrane; P-type ATPase subfamily IIB (PMCA)

Function

• high-affinity Ca+2-transporting system of plasma membranes
• only plasma membrane Ca+2-transporter in most cells, but quantitatively 2nd to low affinity Na+/Ca+2 exchanger in neurons & cardiac muscle
• PMCA serves to fine tune cytoplasmic Ca+2 with the extracellular space
• PMCA has catalytic properties of ion-motive ATPases of the P type

Compartment

• found in plasma membranes

Alternative splicing

• isoform diversity is enhanced by alternative splicing, with > 20 different transcripts identified

Expression

• one erythrocyte would contain about 700 PMCA molecules

Genetics

• product of a family of four genes located on different chromosomes

More general terms

• transmembrane 10 protein
• Ca+2 ATPase
• plasma membrane protein
• calmodulin binding protein
• PEST protein

More specific terms

• Ca+2 ATPase of plasma membrane, isoform 2 (brain isoform, PMCA2, plasma membrane Ca+2 pump isoform 2, plasma membrane Ca+2 ATPase isoform 2, ATP2B2, PMCA2)
• plasma membrane Ca+2 ATPase-3 (PMCA3, plasma membrane Ca+2 pump isoform 3, plasma membrane Ca+2 ATPase isoform 3, ATP2B3)
• plasma membrane Ca+2 ATPase-4 (PMCA4, plasma membrane Ca+2 pump isoform 4, plasma membrane Ca+2 ATPase isoform 4, matrix-remodeling-associated protein 1, ATP2B4, ATP2B2, MXRA1)
• plasma membrane calcium-transporting ATPase 1 (PMCA1)