Ca+2 ATPase of plasma membrane, isoform 2 (brain isoform, PMCA2, plasma membrane Ca+2 pump isoform 2, plasma membrane Ca+2 ATPase isoform 2, ATP2B2, PMCA2)

Function

• catalyzes hydrolysis of ATP coupled with transport of Ca+2 out of the cell, Mg+2 dependent
• isoform 2b interacts with
  • SAP90, SAP93, SAP97
  • PDZ domain of NHERF2
  • PISP

Alternative splicing

6 isoforms

Expression

• mainly expressed in cerebral cortex
• found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney & lung

Genetics

gene locus: 3p25.3

More general terms

• Ca+2 ATPase of plasma membrane
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01814.html
• OMIM: https://mirror.omim.org/entry/108733
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=491