plasma membrane calcium-transporting ATPase 1 (PMCA1)

Function

• catalyzes hydrolysis of ATP coupled with transport of Ca+2 out of the cell, Mg+2 dependent

Alternative splicing

6 isoforms; A-E & K

Expression

• isoform B: ubiquitous
• isoform C: cerebral cortex, skeletal muscle, cardiac muscle
• isoform K: small intestine & liver

Genetics

gene locus: 12q21.3

More general terms

• Ca+2 ATPase of plasma membrane

Database

• OMIM: https://mirror.omim.org/entry/108731
• UniProt: http://www.uniprot.org/uniprot/P20020.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=490