plasma membrane Ca+2 ATPase-3 (PMCA3, plasma membrane Ca+2 pump isoform 3, plasma membrane Ca+2 ATPase isoform 3, ATP2B3)

Function

• catalyzes hydrolysis of ATP coupled with transport of Ca+2 out of the cell, Mg+2 dependent

Structure

• belongs to the cation transport ATPase (P-type) family, type IIB subfamily

Compartment

cell membrane

Alternative splicing

named isoforms=8

Expression

• isoforms XE & XB are the most abundant isoforms & are detected at low levels in brain & fetal skeletal muscle
• other isoforms are only found at lower levels & not in fetal tissues

Genetics

Gene locus: Xq28

More general terms

• Ca+2 ATPase of plasma membrane
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/300014
• UniProt: http://www.uniprot.org/uniprot/Q16720.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=492