plasma membrane Ca+2 ATPase-4 (PMCA4, plasma membrane Ca+2 pump isoform 4, plasma membrane Ca+2 ATPase isoform 4, matrix-remodeling-associated protein 1, ATP2B4, ATP2B2, MXRA1)

Function

• catalyzes hydrolysis of ATP coupled with transport of Ca+2 out of the cell, Mg+2 dependent
• isoform 4b interacts with
  • SAP93, SAP97, SAP102
  • PSD95
  • PISP
  • RASSF1A, RASSF1C, RASSF1E

Alternative splicing

named isoforms=8

Expression

• isoform XB is the most abundant isoform & is expressed ubiquitously
• isoforms containing segment Z have only been detected in heart
• isoforms containing segment A have been found in heart, stomach & brain cortex

Genetics

Gene locus: 1q32.1

More general terms

• Ca+2 ATPase of plasma membrane

Database

• UniProt: http://www.uniprot.org/uniprot/P23634.html
• OMIM: https://mirror.omim.org/entry/108732
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=493