transcription factor E2F7 (E2F-7, E2F7)

Function

• inhibitor of E2F-dependent transcription
• binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'
• appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession
• modulates the activity of other E2F proteins, such as E2F1, probably by competing or displacing activating E2Fs from promoter binding
• self-associates
• probably binds DNA as a homodimer

Structure

• both DNA-binding domains are required for DNA-binding & are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer
• belongs to the E2F/DP family

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96AV8.html