SLC2A4 regulator (GLUT4 enhancer factor, GEF, Huntington disease gene regulatory region-binding protein 1, HDBP-1, SLC2A4RG, HDBP1)

Function

• transcription factor involved in SLC2A4 & HD gene transactivation.
• binds to the consensus sequence 5'-GCCGGCG-3'
• interacts with MEF2A

Structure

• contains 1 C2H2-type zinc finger

Compartment

• cytoplasm, nucleus
• shuttles between cytoplasm & nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in heart, skeletal muscle, liver, kidney, pancreas undetectable in lung, placenta or brain
• ubiquitously expressed, with lowest expression in brain & ileum

* two accounts of expression (see UniProt)

More general terms

• transcription factor (TF)
• DNA-binding protein
• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NR83.html