transcriptional activator protein Pur-beta (purine-rich element-binding protein B, PURB)

Function

• binds repeated elements in single-stranded DNA, i.e. purine-rich single strand of the PUR element located upstream of the MYC gene
• role in control of vascular smooth muscle alpha-actin gene transcription as repressor in myoblasts & fibroblasts
• role in transcriptional & translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory element
• modulates constitutive liver galectin-3 gene transcription by binding to its promoter
• role in dendritic transport of a subset of mRNAs

Structure

• homodimer
• heterodimer with PURA
• heterotrimer with PURA & YBX1/Y-box protein 1
• belongs to the PUR DNA-binding protein family

Compartment

nucleus

Pathology

• expressed in myocardium of heart failure patients
• defects in PURB may be a cause of progression of myelodysplastic syndrome towards acute myelogenous leukemia

More general terms

• transcription factor (TF)
• phosphoprotein
• DNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/608887
• UniProt: http://www.uniprot.org/uniprot/Q96QR8.html