SAM pointed domain-containing Ets transcription factor (prostate-derived Ets factor, prostate epithelium-specific Ets transcription factor, prostate-specific Ets, SPDEF, PDEF, PSE)
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Function
- androgen-independent transactivator of the prostate-specific antigen (PSA) promoter (putative)
- binds to 5'-GGAT-3' DNA sequences
- regulation of prostate gland
- transcriptional activator for SERPINB5 promoter
- interacts with the DNA-binding domain of the androgen receptor
- interacts with NKX3-1
Structure
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment
Expression
- expressed in restricted set of primarily hormone-regulated epithelial tissues, prostate gland > mammary gland, salivary gland, ovary
Pathology
- regulation of prostate cancer development (putative)
- expressed in prostate carcinoma cells