Teashirt homolog 1; antigen NY-CO-33; serologically defined colon cancer antigen 33 (TSHZ1, SDCCAG33, TSH1)

Function

• transcriptional regulator involved in developmental processes (putative)
• may act as a transcriptional repressor
• interacts (via homeobox domain) with APBB1 (via PID domain 1) (putative)

Structure

• belongs to the teashirt C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

• expressed in brain

Pathology

• expression is diminished in elderly subjects with Alzheimer disease (post-mortem studies)
• defects in TSHZ1 are the cause of congenital aural atresia

More general terms

• transcription factor (TF)
• C2H2 type zinc finger protein

Additional terms

• adenocarcinoma of the colon &/or rectum

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10194
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10194
• OMIM: https://mirror.omim.org/entry/607842
• OMIM: https://mirror.omim.org/entry/614427
• UniProt: http://www.uniprot.org/uniprot/Q6ZSZ6.html