peregrin; bromodomain & PHD finger-containing protein 1; protein Br140 (BRPF1, BR140)

Function

• component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity
• positively regulates the transcription of RUNX1 & RUNX2
• acetylated by MYST3

Structure

• contains 1 bromo domain
• contains 1 C2H2-type Zn+2 finger
• contains 1 PHD-type Zn+2 finger
• contains 1 PWWP domain

Compartment

• nucleus, cytoplasm
• localization to the nucleus depends on MYST3, ING5 & MEAF6

Alternative splicing

named isoforms=4

Expression

high levels in testis

More general terms

• transcription factor (TF)
• nuclear protein
• C2H2 type zinc finger protein
• phosphoprotein

Component of

• MOZ/MORF complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7862
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7862
• OMIM: https://mirror.omim.org/entry/602410
• UniProt: http://www.uniprot.org/uniprot/P55201.html