inhibitor of growth protein 5; p28ING5 (ING5)

Introduction

May play a role in the regulation of transcription through epigenetic modification of chromatin.

Function

• component of the HBO1 complex
• component of the MOZ/MORF complex
• through chromatin acetylation, may regulate DNA replication & may function as a transcriptional coactivator
• interacts with H3K4me3 & to a lesser extent with H3K4me2
• interacts with EP300 & TP53

Structure

• the PHD-type Zn+2 finger mediates the binding to H3K4me3
• belongs to the ING family
• contains 1 PHD-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• inhibitor of growth protein
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84289
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84289
• OMIM: https://mirror.omim.org/entry/608525
• UniProt: http://www.uniprot.org/uniprot/Q8WYH8.html