regulatory factor X (RFX)

Function

• binds the X1 box of MHC-II promoters
• forms cooperative DNA binding complexes with X2BP & CBF/NF-Y
• associates with CIITA/MHC2TA to form an active transcriptional complex

Structure

• RFX consists of at least 3 different subunits: RFXAP, RFX5 & RFX-B/RFXANK; with each subunit representing a separate complementation group

Pathology

• defects in the RFX-CIITA transcriptional complex are associated with bare lymphocyte syndrome type-2

More general terms

• multisubunit protein
• transcription factor (TF)

Additional terms

• DNA-binding protein RFX2; regulatory factor X 2 (RFX2)