DNA-binding protein RFX5; regulatory factor X 5 (RFX5)

Function

• component of regulatory factor X (RFX)
• activates transcription from class II MHC promoters
• recognizes X-boxes
• mediates cooperative binding between RFX & NF-Y
• phosphorylated

Structure

• the N-terminus is required for its association with RFXANK & RFXAP, for assembly of the RFX complex, & for binding of this the RFX complex to its X box target site in the MHC-II promoter
• the C-terminus mediates cooperative binding between the RFX complex & NF-Y
• belongs to the RFX family
• contains 1 H-T-H motif winged-type DNA-binding domain

Compartment

nucleus

Expression

ubiquitous

Pathology

• defects in RFX5 are a cause of bare lymphocyte syndrome-2

More general terms

• protein subunit
• DNA-binding protein

Component of

• regulatory factor X (RFX)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5993
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5993
• OMIM: https://mirror.omim.org/entry/209920
• OMIM: https://mirror.omim.org/entry/601863
• UniProt: http://www.uniprot.org/uniprot/P48382.html