transcriptional enhancer factor TEF-1; TEA domain family member 1; TEAD-1; protein GT-IIC; transcription factor 13; NTEF-1 (TEAD1 TCF13 TEF1)

Function

• binds specifically & cooperatively to the SPH & GT-IIC enhancers (5'-GTGGAATGT-3') & activates transcription in vivo in a cell-specific manner
• the activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor
• involved in cardiac development
• binds to the M-CAT motif

Structure

contains 1 TEA DNA-binding domain

Compartment

nucleus

Expression

• preferentially expressed in skeletal muscle
• lower levels in pancreas, placenta, & heart

Pathology

• defects in TEAD1 are the cause of
• Sveinsson chorioretinal atrophy

More general terms

• transcription factor (TF)
• DNA-binding protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7003
• OMIM: https://mirror.omim.org/entry/108985
• OMIM: https://mirror.omim.org/entry/189967
• UniProt: http://www.uniprot.org/uniprot/P28347.html