ski proto-oncogene protein (c-ski, ski)
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Function
- transcriptional corepressor
- role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage
- interacts with Smad2, Smad3, & Smad4, but less so with Smad1 & Smad5
- suppresses signaling of GF-beta & bone morphogenetic proteins (BMPs) through binding to Smad proteins
- interacts with HIPK2
- part of a complex with HIPK2 & Smad1/Smad2/Smad3
Structure
belongs to the SKI family
Compartment
More general terms
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 986
- ↑ Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K. Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Mol Biol Cell. 2004 Mar;15(3):963-72. Epub 2003 Dec 29. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14699069
- ↑ UniProt http://www.uniprot.org/uniprot/P12755.html