Killer cell lectin-like receptor subfamily G member 1 (mast cell function-associated antigen, MAFA-like receptor, ITIM-containing receptor MAFA-L, C-type lectin domain family 15 member A) (KLRG1 CLEC15A MAFA MAFAL)

Function

• plays an inhibitory role on natural killer (NK) cells & T-cell functions upon binding to their ligands
• binds E-cadherin/CDH1, N-cadherin/CDH2 & R-cadherin/CDH4
• forms monomer & homodimer; disulfide-linked
• interacts (via phosphorylated ITIM motif) with PTPN11 & INPP5D

Structure

• contains 1 copy of ITIM motif
• contains 1 C-type lectin domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed specifically on natural killer cells (NK cells) & T-cells, mainly CD8 T-cells

Pathology

induced by pathogens & viruses infections

More general terms

• killer cell lectin like receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1021
• OMIM: https://mirror.omim.org/entry/604874
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10219
• UniProt: http://www.uniprot.org/uniprot/Q96E93.html