C-type lectin domain family 7 member A (dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, dectin-1, beta-glucan receptor, C-type lectin superfamily member 12, CLEC7A, BGR, CLECSF12 DECTIN1 ORFNames=UNQ539/PRO1082)
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Function
- lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, i.e. cell wall constituents from pathogenic bacteria & fungi
- necessary for TLR2-mediated inflammatory response & for TLR2-mediated activation of NF-kappa-B
- enhances cytokine production in macrophages & dendritic cells
- mediates production of reactive oxygen species in the cell
- mediates phagocytosis of C.albicans conidia
- binds T-cells in a way that does not involve their surface glycans
- role in T-cell activation, stimulates T-cell proliferation
- isoform 5 interacts with RANBP9
- phosphorylated on Tyr in response to glucan binding
Structure
- contains 1 C-type lectin domain
Compartment
Alternative splicing
named isoforms=8
Expression
- highly expressed in peripheral blood leukocytes & dendritic cells
- detected in spleen, bone marrow, lung, muscle, stomach, placenta
- up-regulated during differentiation from monocytes into dendritic cells