interleukin-29; IL-29; cytokine Zcyto21; interferon lambda-1; IFN-lambda-1 (IL29, IFNL1, ZCYTO21)

Function

• cytokine with immunomodulatory activity
• antiviral immunity
• up-regulates MHC class I antigen expression
• ligand for the heterodimeric class II cytokine receptor IL10RB/IL28RA
• signals through the Jak-STAT pathway.

Compartment

secreted

Expression

induction by viral infections or dsRNA

More general terms

• interleukin
• interferon [IFN]-lambda (IFNL)
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=282618
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:282618
• OMIM: https://mirror.omim.org/entry/607403
• UniProt: http://www.uniprot.org/uniprot/Q8IU54.html