CD316 (immunoglobulin superfamily member 8, CD81 partner 3, glu-Trp-Ile EWI motif-containing protein 2, EWI-2, keratinocytes-associated transmembrane protein 4, KCT-4, LIR-D1, CD316 antigen, IGSF8, CD81P3, EWI2, KCT4)
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Function
- role in diverse fonctions ascribed to CD81 & CD9, including oocytes fertilization (putative)
- regulates proliferation & differentiation of keratinocytes (putative)
- regulates cell motility (putative)
- suppress T-cell mobility coordinately with CD81
- associates with CD82 to suppress prostate cancer cell migration
- regulates epidermoid cell reaggregation & motility on laminin-5 with CD9 & CD81 as key linkers
- role on integrin-dependent morphology & motility functions
- regules neurite outgrowth & maintenance of the neural network in adult brain (putative)
- interacts with CD82, CD81/tetraspanin-28 & CD9/tetraspanin-29
- interacts with integrin alpha-3, integrin beta-1 & integrin alpha-4-beta-1
Structure
- contains 4 Ig-like C2-type domains (immunoglobulin-like) Ig-like C2-type domains 3 & 4 required for interaction with CD81
Compartment
membrane
Alternative splicing
named isoforms=3
Expression
- expressed in brain, kidney, testis, liver, placenta > other tissues
- expressed on a majority of B-cells, T-cells, & NK cells but not on monocytes, neutrophils or platelets
Pathology
- role in diverse fonctions ascribed to CD81 & CD9, including hepatitis C virus function