CD82 (metastasis suppressor Kangai 1, KAI1, C33 antigen, IA4, inducible membrane protein R2, tetraspanin-27, Tspan-27)
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Function
- roles in signal transduction & T cell activation.
- CD82 expression correlates with p53 expression.
- associates with CD4 or CD8 & gives costimulatory signals for T cell receptor pathway
- CD82 cross-linking promotes activation of human monocytic cell lines
Expression
- activated/differentiated hematopoietic cells
- negative antibody staining in erythrocytes
Pathology
- prostate cancer antimetastasis gene (protein) kang ai (KAI1)
- transfection of CD82 inhibited metastatic potential of prostate cancer cells in rat
- CD82 expression is correlated with metastatic potential in humans
More general terms
References
- ↑ Protein Reviews on the Web http://mpr.nci.nih.gov/prow/guide/1511855925_g.htm
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 20 May 2003