tumor endothelial marker 1; endosialin; CD248 antigen (CD248, CD164L1, TEM1)
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Function
- role in cell adhesion
- associated with angiogenesis in the embryo & in neoplasms
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
- expressed by stromal cells of proliferating tissues during embryogenesis & postnatally in tumors & inflammatory lesions[2]
- expressed in tumor endothelial cells but not appreciably in normal endothelial cells
- expressed in metastatic lesions of the liver, angiogenesis of corpus luteum formation, wound healing
- expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels
- expressed in stromal fibroblasts[1]
More general terms
References
- ↑ 1.0 1.1 UniProt http://www.uniprot.org/uniprot/Q9HCU0.html
- ↑ 2.0 2.1 Valdez Y, Maia M, Conway EM. CD248: reviewing its role in health and disease. Curr Drug Targets. 2012 Mar;13(3):432-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22206249