CD118; leukemia inhibitory factor [LIF] receptor alpha, LIF binding protein; LIF receptor alpha; LIF-R (LIFR, LIFRA)
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Function
- signal-transducing molecule
- may have a common pathway with IL6ST
- soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells
- forms heterodimer with IL6ST
Structure
- WSXWS motif appears to be necessary for proper protein folding & thereby efficient intracellular transport & cell-surface receptor binding
- box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 2 subfamily
- contains 6 fibronectin F3 modules
Compartment
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing
named isoforms=2
Pathology
- defects in LIFR are the cause of Stueve-Wiedemann syndrome
- chromosomal translocation t(5;8)(p13;q12) involving LIFR with PLAG1 may be a cause of salivary gland pleiomorphic adenomas
More general terms
Additional terms
Component of
References
- ↑ Miyajima A, Hara T, Kitamura T. Common subunits of cytokine receptors and the functional redundancy of cytokines. Trends Biochem Sci. 1992 Oct;17(10):378-82. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1455505
- ↑ Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992 Mar 13;255(5050):1434-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1542794
- ↑ Taga T & Kishimoto T Cytokine receptors and signal transduction. FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ UniProt http://www.uniprot.org/uniprot/P42702.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=LIFR