CD38; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10

Function

• synthesizes cyclic ADP-ribose
• also has cADPr hydrolase activity
  • ATP inhibits the hydrolase activity
• involved in adhesion between leukocytes & endothelial cells

Structure

belongs to the ADP-ribosyl cyclase family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

(widely expressed)

• plasma cells (strong immunoreactivity)
• lymphoid progenitor cells
• thymocytes
• NK cells
• B cells
• T cells
• monocytes
• erythroid & myeloid precursors
• brain
• muscle
• kidney
• pancreas
• liver
• testis
• ovary
• placenta

Pathology

• expressed in:
  • lymphoma
  • neuroblastoma

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• CD antigen
• glycoprotein
• membrane protein
• hydrolase

Additional terms

• lymphoblast

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:952
• OMIM: https://mirror.omim.org/entry/107270
• UniProt: http://www.uniprot.org/uniprot/P28907.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=952