pericentriolar material 1 protein (PCM-1, hPCM-1, PCM1)

Function

• required for centrosome assembly & function
• essential for correct localization of several centrosomal proteins including CEP250, CETN3, PCNT & NEK2
• required to anchor microtubules to the centrosome
• self-associates
• interacts with BBS4, BBS8, CETN3, HAP1, NDE1 & NDEL1

Structure

• belongs to the PCM1 family

Compartment

• cytoplasm, centrosome
• localizes to cytoplasmic granules which are enriched around the centrosome
  • centrosomal enrichment requires microtubules & dynein
• majority of the protein dissociates from the centrosome during metaphase & subsequently localizes to cleavage site in telophase
• phosphorylated upon DNA damage, probably by ATM or ATR

Alternative splicing

named isoforms=3

Expression

• expressed in blood, bone marrow, breast, lymph node, ovary & thyroid

Pathology

• expression is reduced in breast & ovarian cancer.
• chromosomal translocation t(8;10)(p21.3;q11.2) involving PCM1 with RET is found in thyroid papillary carcinoma the translocation links the protein kinase domain of RET to the major portion of PCM1
• chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical CML & T-cell lymphoma
• chromosomal translocation t(8;9)(p22;p24) involving PCM1 with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/188550
• OMIM: https://mirror.omim.org/entry/600299
• UniProt: http://www.uniprot.org/uniprot/Q15154.html