apoptosis-stimulating of p53 protein 1; protein phosphatase 1 regulatory subunit 13B (PPP1R13B, ASPP1, KIAA0771)

Function

• role in regulation of apoptosis via its interaction with p53/TP53
• regulates TP53 by enhancing DNA binding & transactivation function of TP53 on promoters of proapoptotic genes in vivo
• interacts with TP53

Structure

• the ankyrin repeats & the SH3 domain are required for specific interactions with TP53
• belongs to the ASPP family
• contains 2 ANK repeats
• contains 1 SH3 domain

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic
• some fraction is nuclear

Expression

• reduced expression in breast carcinomas expressing a wild-type TP53 protein

Notes

• in contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1
• this name was given due to its similarity with a protein that binds to protein phosphatase 1

More general terms

• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23368
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23368
• OMIM: https://mirror.omim.org/entry/606455
• UniProt: http://www.uniprot.org/uniprot/Q96KQ4.html