A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kD; AKAP 149; dual specificity A-kinase-anchoring protein 1; D-AKAP-1; protein kinase A-anchoring protein 1; PRKA1; spermatid A-kinase anchor protein 84; S-AKAP84 (AKAP1, AKAP149, PRKA1)

Function

• binds to type I & II regulatory subunits of protein kinase A & anchors them to the cytoplasmic face of the mitochondrial outer membrane

Structure

• RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA-R-subunit dimer
• contains 1 KH domain
• contains 1 Tudor domain

Compartment

mitochondrial outer membrane (putative)

Alternative splicing

• named isoforms=2
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• AKAP149 is highly expressed in prostate & small intestine
• S-AKAP84 is expressed in kidney, pancreas, liver, lung & brain
• AKAP149 is also expressed in colon carcinoma

More general terms

• A-kinase anchor protein
• mitochondrial protein
• RNA-binding protein
• phosphoprotein

Additional terms

• protein kinase A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8165
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8165
• OMIM: https://mirror.omim.org/entry/602449
• UniProt: http://www.uniprot.org/uniprot/Q92667.html