cleavage stimulation factor 64 kD subunit; CSTF 64 kD subunit; CstF-64; CF-1 64 kD subunit (CSTF2)

Function

• one of the multiple factors required for polyadenylation & 3'-end cleavage of mammalian pre-mRNAs
• this subunit is directly involved in the binding to pre-mRNAs (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR
• component of the CSTF complex
• CSTF2 directly interacts with CSTF3, SYMPK & RPO2TC1
• interacts with HSF1 in heat-stressed cells
• interacts with FIP1L1

Structure

contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

up-regulated during the G0 to S phase transition

More general terms

• RNA-binding protein
• protein subunit
• phosphoprotein
• nuclear protein

Component of

• cleavage stimulation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1478
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1478
• OMIM: https://mirror.omim.org/entry/600368
• UniProt: http://www.uniprot.org/uniprot/P33240.html