Nicalin (nicastrin-like protein, NCLN)
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Function
- may antagonize Nodal signaling & subsequent organization of axial structures during mesodermal patterning
- interacts with NOMO2
- due to the strong similarity between NOMO1, NOMO2 & NOMO3, it probably also interacts with NOMO1 & NOMO3
- participates in a large protein complex, which is not related to the gamma-secretase complex
Structure
belongs to the nicastrin family
Compartment
endoplasmic reticulum membrane
Alternative splicing
named isoforms=2
Expression
- highly expressed in pancreas & skeletal muscle &, at lower levels, in heart