TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; killer-activating receptor-associated protein; KAR-associated protein (TYROBP, DAP12, KARAP)

Function

• non-covalently associates with activating receptors of the CD300 family
• cross-linking of CD300-TYROBP complexes results in cellular activation
• Tyr phosphorylated
• interacts with SIRPB1 & TREM1
• interacts with CLECSF5
• interacts with SIGLEC14
• interacts with CD300LB & CD300E
• interacts with CD300D (putative)

Structure

• homodimer; disulfide-linked
• belongs to the TYROBP family

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

• named isoforms=2

Expression

• expressed at low levels in the early development of the hematopoietic system & in the promonocytic stage & at high levels in mature monocytes
• expressed in hematological cells & tissues such as peripheral blood leukocytes & spleen
• also found in bone marrow, lymph nodes, placenta, lung & liver
• expressed at lower levels in different parts of the brain especially in the basal ganglia & corpus callosum

Pathology

• defects in TYROBP are a cause of Nasu-Hakola disease

More general terms

• receptor
• phosphoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7305
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7305
• OMIM: https://mirror.omim.org/entry/221770
• OMIM: https://mirror.omim.org/entry/604142
• UniProt: http://www.uniprot.org/uniprot/O43914.html