triggering receptor expressed on myeloid cells 1; triggering receptor expressed on monocytes 1; TREM-1 (TREM1)

Function

• stimulates neutrophil & monocyte-mediated inflammatory responses
• triggers release of pro-inflammatory chemokines & cytokines
• increases surface expression of inflammatory cell activation markers
• amplifies inflammatory responses triggered by bacterial & fungal infections
• mediator of septic shock
• interacts with TYROBP

Structure

• glycosylated
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

• expressed in adult liver, lung, spleen, lymph node, placenta, spinal cord, heart tissues
• expressed in peripheral blood leukocytes > bone marrow
• expressed in normal cells > malignant cells
• expressed with differentiation of monocytes

Pathology

• up-regulated by bacteria, fungi, lipopolysaccharides
• strongly expressed in acute inflammatory lesions caused by bacteria, fungi

More general terms

• triggering receptor expressed on myeloid cells

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5421
• OMIM: https://mirror.omim.org/entry/605085
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54210
• UniProt: http://www.uniprot.org/uniprot/Q9NP99.html