C-type lectin domain family 5 member A; C-type lectin superfamily member 5; myeloid DAP12-associating lectin 1; MDL-1 (CLEC5A CLECSF5 MDL1)

Function

• may be involved in proinflammatory activation of myeloid cells via TYROBP-mediated signaling (Ca+2-dependent)
• interacts with TYROBP

Structure

• contains 1 C-type lectin domain

Compartment

• membrane; single-pass type 2 membrane protein (probable)

Alternative splicing

named isoforms=2

Expression

• expressed in peripheral blood monocytes & in the monocyte/macrophage cell lines U937 & monomac6
• not expressed in cell lines of other origins
• expression is down-regulated when monocytes differentiate into dendritic cells

More general terms

• C-type lectin superfamily

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23601
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23601
• OMIM: https://mirror.omim.org/entry/604987
• UniProt: http://www.uniprot.org/uniprot/Q9NY25.html