sialic acid-binding Ig-like lectin 14 (siglec-14, SIGLEC14)

Function

• putative adhesion molecule
• sialic acid-binding paired
• receptor which may activate associated receptors
• interacts with TYROBP

Structure

• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 2 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

membrane

Expression

• mainly expressed in hematopoietic tissues including bone marrow, spleen & fetal liver
• also detected in lung & testis

More general terms

• glycoprotein
• membrane protein
• adhesion protein
• immunoglobulin superfamily protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q08ET2.html