CD300B; CMRF35-like molecule 7; CLM-7; CMRF35-A2; CD300 antigen-like family member B; immune receptor expressed on myeloid cells 3; IREM-3; triggering receptor expressed on myeloid cells 5; TREM-5, Leukocyte mono-Ig-like receptor 5; CD300b antigen (CD300LB, CLM7, CMRF35A2, IREM3, LMIR5, TREM5, UNQ2530/PRO6029)

Function

• acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, & also independently by recruitement of GRB2
• interacts with TYROBP, which enhances cell surface expression & activation properties
• interacts with GRB2 in the presence of FYN
• phosphorylation on Tyr-188 by FYN is required for interaction with GRB2

Structure

• belongs to the CD300 family
• contains 1 Ig-like V-type domain (immunoglobulin-like) domain

Compartment

cell membrane

Expression

expressed exclusively in myeloid lineages

More general terms

• receptor
• CD300 family protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1245
• UniProt: http://www.uniprot.org/uniprot/A8K4G0.html