HERV-W 7q21.2 provirus ancestral Env polyprotein; envelope polyprotein gPr73; HERV-7q Envelope protein; HERV-W envelope protein; syncytin; syncytin-1; enverin; Env-W [Contains: surface protein (SU) (gp50); transmembrane protein (TM) (gp24)] (ERVWE1)
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Introduction
Also see endogenous retroviral envelope polyprotein
Expression
- expressed in placental syncytiotrophoblast > testis > adrenal, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen,thymus, thyroid, brain, trachea
Pathology
- both mRNA & protein levels are significantly increased in brain of patients with multiple sclerosis, particularly in astrocytes & microglia
- increased expression in astrocytes induces the release of iNOS, IL-1 beta & redox reactants resulting in oligodendrocyte damage & death
- can make pseudotypes with HIV-1 virions & confer infectivity
- can induce cellular resistance to spleen necrosis virus in vitro
Genetics
Comparative biology
- orthologs in Pan troglodytes, Gorilla gorilla, Pongo pygmaeus & Hylobates moloch
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UQF0.html
- ↑ Human Endogenous Retrovirus Database (HERVd) http://herv.img.cas.cz/cgi-bin/draw_full_element.cgi?fid=41573
- ↑ Protein Spotlight A virus for life - Issue 50 of September 2004 http://www.expasy.org/spotlight/back_issues/sptlt050.shtml