endogenous retroviral envelope polyprotein

Introduction

Endogenous retroviral proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition & membrane fusion during early infection.

• surface (SU) protein mediates receptor recognition
• transmembrane (TM) protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain
• SU & TM proteins form a heterodimer attached by noncovalent interactions or by a labile interchain disulfide bond
• another hydrophobic domain, called fusion peptide, mediates fusion of the membrane with the target cell membrane
• CKS-17 immunosuppressive domain is present in many retroviral envelope proteins
• CXXC motif may form labile disulfide bond with CX6CC motif present in TM

More general terms

• endogenous retroviral protein

More specific terms

• HERV-F(c)1 Xq21.33 provirus ancestral Env polyprotein (Fc1env, HERV-Fc1env, [Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-F(c)2-7q36.2 provirus ancestral Env polyprotein (Fc2deltaenv, [Includes: Surface protein (SU); Truncated transmembrane protein (TM)])
• HERV-FRD 6p24.1 provirus ancestral Env polyprotein; HERV-FRD; Syncytin-2 [Contains: Surface protein (SU); Transmembrane protein (TM)] (ERVFRDE1, ERVFRD-1)
• HERV-H 2q24.1 provirus ancestral Env polyprotein (Env protein HERV-H/p59, HERV-H/env59, [Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-H 2q24.3 provirus ancestral Env polyprotein (Env protein HERV-H/p62, Env protein HERV-H19, HERV-H/env62, Env protein HERV-Hcl.3, [Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-K 11q22.1 provirus ancestral Env polyprotein ([Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-K 12q14.1 provirus ancestral Env polyprotein (EnvK1 protein, [Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-K 16p3.3 provirus ancestral Env polyprotein ([Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-K 19p13.11 provirus ancestral Env polyprotein (HERV-K113 envelope protein, EnvK5 protein, [Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-K 19q12 provirus ancestral Env polyprotein; envelope polyprotein; HERV-K(C19) envelope protein; EnvK3 protein [contains: surface protein (SU); transmembrane protein (TM)]
• HERV-K 1p13.3 provirus ancestral Env polyprotein ([Includes: Truncated surface protein (SU)])
• HERV-K 1q22 provirus ancestral Env polyprotein; HERV-K102 envelope protein; HERV-K(III) envelope protein [Contains: surface protein (SU); transmembrane protein (TM)]
• HERV-K 22q11.21 provirus ancestral Env polyprotein; HERV-K101 envelope protein [Contains: surface protein (SU); transmembrane protein (TM)]
• HERV-K 3q12.3 provirus ancestral Env polyprotein; HERV-K(II) envelope protein [Includes: truncated surface protein (SU)] (ERVK5)
• HERV-K 6q14.1 provirus ancestral Env polyprotein; HERV-K109 envelope protein; HERV-K(C6) envelope protein; EnvK4 protein [Contains: surface protein (SU); transmembrane protein (TM)]
• HERV-K 7q22.1 provirus ancestral Env polyprotein; HERV-K(HML-2.HOM) envelope protein,HERV-K108 envelope protein, HERV-K(C7) envelope protein; EnvK2 protein [Contains: surface protein (SU); transmembrane protein (TM)] (ERVK6)
• HERV-K 8p23.1 provirus ancestral Env polyprotein (HERV-K115 envelope protein, EnvK6 protein, [Contains: Surface protein (SU); Transmembrane protein (TM)])
• HERV-K{1q23.3} provirus ancestral Env polyprotein (HERV-K18 envelope protein, envelope polyprotein, HERV-K18 envelope protein, HERV-K110 envelope protein, IDDMK1-2 22 envelope protein, HERV-K(C1a) envelope protein, HERV-K18 superantigen, IDDMK1,2 22 su...
• HERV-R 7q21.2 provirus ancestral Env polyprotein; ERV3 envelope protein; HERV-R envelope protein, [Contains: Surface protein (SU); Transmembrane protein (TM)] (ERV3, ERV3-1)
• HERV-R(b); HERV-R(b) Env protein [Includes: surface protein domain (SU); transmembrane protein domain (TM)]
• HERV-T 19q13.11 provirus ancestral Env polyprotein (HERV-T Env protein [Includes: Surface protein (SU); Transmembrane protein (TM)])
• HERV-V 19q13.41 provirus ancestral Env polyprotein 1; endogenous retrovirus group V, member 1 (ERVV-1, ENVV1)
• HERV-V 19q13.41 provirus ancestral Env polyprotein 2; endogenous retrovirus group V, member 2 (ERVV-2, ENVV2)
• HERV-W 7q21.2 provirus ancestral Env polyprotein; envelope polyprotein gPr73; HERV-7q Envelope protein; HERV-W envelope protein; syncytin; syncytin-1; enverin; Env-W [Contains: surface protein (SU) (gp50); transmembrane protein (TM) (gp24)] (ERVWE1)

Additional terms

• viral ENV protein