HERV-FRD 6p24.1 provirus ancestral Env polyprotein; HERV-FRD; Syncytin-2 [Contains: Surface protein (SU); Transmembrane protein (TM)] (ERVFRDE1, ERVFRD-1)

Introduction

Also see endogenous retroviral envelope polyprotein

Function

• has retained its original fusogenic properties
• can make pseudotypes with MLV, HIV-1 or SIV-1 virions & confer infectivity

Expression

• expressed in placenta > adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea Comarative biology:
• ortholog in old-world & new-world monkeys, but not in prosimians

Genetics

HERV-FRD subgenomic RNA has been observed

More general terms

• endogenous retroviral envelope polyprotein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P60508.html