platelet glycoprotein 6 (GP6, GPVI)

Function

• collagen receptor
• collagen-induced platelet adhesion & activation
• platelet procoagulant activity with subsequent thrombin & fibrin formation
• procoagulant function contributing to arterial & venous thrombus formation
• signaling pathway involves the FcR gamma-chain, Src kinases (likely Fyn/Lyn), the adapter protein LAT & leads to the activation of phospholipase C gamma2
• associated with Fc receptor gamma chain
• GP6-FcRgamma complex is associated with the Src kinase family Fyn & Lyn

Compartment

membrane

Alternative splicing

named isoforms=3 Megakaryocytes & platelets

Pathology

• deficiency in GP6 results in a mild hemorrhagic diathesis platelets fail to aggregate in response to collagen

More general terms

• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/605546
• UniProt: http://www.uniprot.org/uniprot/Q9HCN6.html