signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD172b (SIRPB1)

Function

• immunoglobulin-like cell surface receptor involved in negative regulation of receptor tyrosine kinase-coupled signaling processes
• also participates in recruitment of tyrosine kinase SYK
• interacts with TYROBP; interaction results in recruitment of SYK

Structure

• N-glycosylated
• contains 2 Ig-like C1-type (immunoglobulin-like) domains
• contains 1 Ig-like V-type domain

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=3

Expression

• expressed in monocytes & dendritic cells

More general terms

• signal-regulatory protein-beta (SIRP-beta)
• glycoprotein
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10326
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10326
• OMIM: https://mirror.omim.org/entry/603889
• UniProt: http://www.uniprot.org/uniprot/O00241.html