G-protein coupled receptor 132 (G2 accumulation protein, GPR132, G2A)

Function

• orphan receptor
• activates a G-alpha protein, most likely Gq-alpha
• apoptosis
• functions at G2/M checkpoint to delay mitosis
• slows proliferation
• promotes repair of damaged DNA
• internalized & accumulated in endosomal compartments
• LPC triggers the relocalization from the endosomal compartment to the cell surface
• induced by stress and DNA-damaging agents

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane
• internalized & accumulated in endosomal compartments
• lysophosphatidylcholine triggers the relocalization from the endosomal compartment to the cell surface (putative)

Alternative splicing

named isoforms=2

Expression

expressed in macrophages, spleen, thymus > heart, lung

Pathology

-expressed in atherosclerotic plaques, around lipid core & at shoulder region

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• orphan receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2993
• OMIM: https://mirror.omim.org/entry/606167
• UniProt: http://www.uniprot.org/uniprot/Q9UNW8.html