trace amine-associated receptor 1 (TAAR1, trace amine receptor 1, TaR-1)

Function

• receptor for trace amines
  • beta-phenylethylamine
  • p-tyramine
  • octopamine
  • tryptamine.
• activates Gs-proteins which activate adenylate cyclase

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• integral membrane protein

Expression

• central nervous system
  • amydala
  • cerebellum
  • hippocampus
  • hypothalamus
  • medulla
  • pontine reticular formation
  • pituitary
• peripheral nervous system
  • dorsal root ganglia
• stomach
• kidney
• lung
• small intestine
• liver
• pancreas
• prostate
• spleen

Pathology

• may be target for development of drugs to treat schizophrenia

More general terms

• trace amine-associated receptor (TAAR)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1348
• OMIM: https://mirror.omim.org/entry/609333
• UniProt: http://www.uniprot.org/uniprot/Q96RJ0.html