C3a anaphylatoxin chemotactic receptor; C3a-R; C3AR (C3AR1 AZ3B C3R1 HNFAG09)

Function

• receptor for the chemotactic & inflammatory peptide anaphylatoxin C3a
• stimulates chemotaxis, granule enzyme release & superoxide production
• sulfation of Tyr-174 is essential for binding of C3a anaphylatoxin

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, & endothelial cells
• mostly expressed in lymphoid tissues

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:719
• OMIM: https://mirror.omim.org/entry/605246
• UniProt: http://www.uniprot.org/uniprot/Q16581.html