mullerian-inhibiting factor; anti-mullerian hormone; AMH; mullerian-inhibiting substance; MIS (AMH, MIF)

Function

• responsible for regression of mullerian ducts in males
• binds to & activates its receptor AMHR2
• able to inhibit growth of tumors derived from tissues of mullerian duct origin
• can inhibit the autophosphorylation of the EGF receptor in vitro
  • does not compete with EGF for EGF receptor binding sites

Structure

• homodimer; disulfide-linked
• belongs to the TGF-beta family
• member of superfamily of proteins that includes TGF-beta, inhibins, & activins

Compartment

secreted

Expression

• expressed by Sertoli cells of the testis

Pathology

• defects in AMH are the cause of persistent mullerian duct syndrome type 1

More general terms

• glycoprotein
• oligomerizing protein
• secreted protein
• TGF-beta family protein

Additional terms

• anti-Mullerian hormone type-2 receptor; anti-Mullerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII (AMHR2, AMHR)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=268
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:268
• OMIM: https://mirror.omim.org/entry/261550
• OMIM: https://mirror.omim.org/entry/600957
• UniProt: http://www.uniprot.org/uniprot/P03971.html