anti-Mullerian hormone type-2 receptor; anti-Mullerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII (AMHR2, AMHR)

Function

• receptor for mullerian inhibitory factor
• on ligand binding, forms a receptor complex consisting of two type 2 & two type 1 transmembrane serine/threonine kinases
• type 2 receptors phosphorylate & activate type 1 receptors which autophosphorylate, then bind & activate SMAD transcriptional regulators

Cofactor: Mg+2 or Mn+2 (putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
• contains 1 protein kinase domain

Compartment

membrane

Pathology

• defects in AMHR2 are the cause of persistent Mullerian duct syndrome type 2

More general terms

• cell surface receptor
• serine/threonine kinase
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:269
• OMIM: https://mirror.omim.org/entry/261550
• OMIM: https://mirror.omim.org/entry/600956
• UniProt: http://www.uniprot.org/uniprot/Q16671.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=269