phospholipase A2 group 7; platelet-activating factor acetylhydrolase; PAF acetylhydrolase; PAF 2-acylhydrolase; LDL-associated phospholipase A2; LDL-PLA2; lipoprotein-associated phospholipase A2; 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase (PAFAH, PLA2G7)

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Function

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

Structure

Compartment

secreted, extracellular space

Expression

Pathology

Polymorphism

Comparative biology

  • there is apparently an intracellular enzyme of bovine brain that shares no sequence similarity outside the region of the active site

More general terms

Additional terms

References

  1. Tjoelker LW et al Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374:549 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7700381
  2. UniProt http://www.uniprot.org/uniprot/Q13093.html
  3. SeattleSNPs http://pga.gs.washington.edu/data/pla2g7/
  4. 4.0 4.1 Young K, Fairchild DG, Di Francesco L FDA Clears Test to Help Predict Coronary Heart Disease Risk Physician's First Watch, Dec 17, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
    FDA News Release. December 15, 2014 FDA clears test that helps predict the risk of coronary heart disease. Study data show test predicts risk better in black women. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm426799.htm

Database