N6-adenosine-methyltransferase 70 kD subunit (MT-A70, methyltransferase-like protein 3, METTL3, MTA70)

Function

• N6-methyltransferase that methylates adenosine residues of some mRNAs
• N6-methyladenosine is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation
• phosphorylated upon DNA damage, probably by ATM or ATR

S-adenosyl-L-methionine + m(7)G(5')pppAm <--> S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am

Structure

belongs to the MT-A70-like family

Compartment

• nuclear speckle
• colocalizes with speckles in interphase nuclei
• may be associated with nuclear pre-mRNA splicing components

Alternative splicing

named isoforms=2

Expression

• widely expressed at low level
• expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon & peripheral blood leukocytes

More general terms

• methyltransferase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86U44.html