JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B (JMJD2B, JHDM3B, KDM4B, KIAA0876)

Function

• histone demethylase
• specifically demethylates Lys-9 of histone H3, thus plays a role in histone code
• does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor H4 Lys-20
• only able to demethylate trimethylated H3 Lys-9, with weaker activity than JMJD2A, JMJD2C & JMJD2D
• demethylation of Lys generates formaldehyde & succinate

Cofactor: binds 1 Fe+2 per subunit

Structure

• belongs to the JHDM3 histone demethylase family
• contains 1 JmjC domain
• contains 1 JmjN domain
• contains 2 PHD-type zinc fingers
• contains 2 Tudor domains
  • 2 Tudor domains recognize & bind methylated histones double Tudor domain has an interdigitated structure unusual fold is required for its ability to bind methylated histone tails

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• JmjC domain-containing protein (JMJD)
• dioxygenase
• histone demethylase
• zinc finger protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O94953.html