lysine-specific demethylase 4C; gene amplified in squamous cell carcinoma 1 protein; GASC-1 protein; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C (KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780)

Function

• histone demethylase
• specifically demethylates Lys-9 & Lys-36 residues of histone H3, thua playing a role in histone code
• does not demethylate histone H3 Lys-4, H3 Lys-27 nor H4 Lys-20
• demethylates trimethylated H3 Lys-9 & H3 Lys-36
• no activity on mono- & dimethylated Lys
• demethylation of Lys generates formaldehyde & succinate

Cofactor:

• binds 1 Fe+2 ion per subunit (putative)

Structure

• the 2 Tudor domains recognize & bind methylated histones
• double Tudor domain has an interdigitated structure & the unusual fold is required for its ability to bind methylated histone tails (putative)
• belongs to the JHDM3 histone demethylase family
• contains 1 JmjC domain
• contains 1 JmjN domain
• contains 2 PHD-type Zn+2 fingers
• contains 2 Tudor domains

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• overexpressed in several esophageal squamous cell carcinomas

More general terms

• histone demethylase
• zinc finger protein
• phosphoprotein

Additional terms

• esophageal cancer
• squamous cell carcinoma (SCC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23081
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23081
• OMIM: https://mirror.omim.org/entry/605469
• UniProt: http://www.uniprot.org/uniprot/Q9H3R0.html