JmjC domain-containing protein 2D; JmjC domain-containing histone demethylation protein 3D; Jumonji domain-containing protein 2D (JMJD2D, JHDM3D, KDM4D)

Function

• histone demethylase
• specifically demethylates Lys-9 of histone H3, thus plays a role in histone code
• does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor histone H4 Lys-20
• demethylates both di- & trimethylated H3 Lys-9 residue, no activity on monomethylated residues
• demethylation of Lys generates formaldehyde & succinate

Cofactor: binds 1 Fe+2 ion per subunit

Structure

• belongs to the JHDM3 histone demethylase family
• contains 1 JmjC domain
• contains 1 JmjN domain

Compartment

nucleus

More general terms

• JmjC domain-containing protein (JMJD)
• dioxygenase
• histone demethylase

Database

• UniProt: http://www.uniprot.org/uniprot/Q6B0I6.html