testis-specific Y-encoded-like protein 2 (TSPY-like 2, differentially expressed nucleolar TGF-beta1 target protein, cell division autoantigen 1, cutaneous T-cell lymphoma-associated antigen se20-4, CTCL tumor antigen se20-4, nuclear protein of 79 kD, NP79, TSPYL2, CDA1, DENTT, TSPX, HRIHFB2216)

Function

• part of the CASK/TRB1/TSPYL2 transcriptional complex
• may inhibit cell proliferation by inducing p53-dependent CDKN1A expression
• interacts with histones
• interacts with CASK
• phosphorylation at Ser-20 &/or Thr-340 impairs function on cell proliferation (probable)

Structure

• belongs to the nucleosome assembly protein (NAP) family

Compartment

• nucleus, cytoplasm (putative)
• enriched in transcriptionally active regions of chromatin in neurons (putative)

Expression

• ubiquitously expressed
• highest levels in brain, testis & heart
• lowest levels in liver & pancreas
• up-regulated in growth-arrested T-cells
• induced by TGFB1 & all-trans retinoic acid in lung cancer cells (at protein level)
• synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation (putative)

Notes

subject to X inactivation

More general terms

• Y chromosome protein
• nuclear protein
• phosphoprotein

Component of

• CASK/TRB1/TSPYL2 transcriptional complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H2G4.html